Luigi's Casa Della Tires could be an actual tire shop, but maybe also an Italian restaurant.
Ramone's House of Body Art could actually be a paint store.
Lizzie's Curio Shop could be an actual Curio shop.
Flo's V8 Cafe could be, not only a gas station, but also, the round building could be a diner.
At the Cozy Cone Motel, their are cones that you can stay in, and you park your car next to the cone.
Of course, everyone needs a doctor, and probably, on Route 66 in the desert, if your town doesn't have a doctor, the next doctor might be miles away, so Doc Hudson's place could have a doctor.
Sarge's Surplus Hut could be an actual surplus hut.
Maybe Fillmore's Taste-In could be a fruit stand, with fruits, vegetables, and drinks made from them.
Lightning's Racing HQ could be a museum.
Their could be a nearby farm that grows those fruits and vegetables at Fillmore's Taste In.
Of course, one of the challenges is finding the perfect place. The place would have to be near a moutain, and their is a tunnel their, with a waterfall at the other end of it.
What other ideas do you have? Tell them in the comments.