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Inside Out antagonists

We all know about Riley, Joy, Sadness, Fear, Anger, and Disgust right? But now one question I have remains, who and what is or are the antgonist(s) of Inside Out? I think this movie will debut the first female main antagonist in pixar history (since there are currently only two and their both secondary!) I already figured that whoever and whatever the main villain is or are, is trying to make Riley stop functioning (it just came to me) but waht else besides emotions could get into Riley's mind? What kind of villains do you all think?

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